Safety profile established in 8 phase 3a trials, where 4,792 patients were treated with Ozempic® alone or in combination with other glucose-lowering agents2

Rates of hypoglycemia2

Regular self-monitoring of blood glucose to adjust the dose of Ozempic® is not required

When used in combination with a sulfonylurea or basal insulin, there was an increased risk of hypoglycemia with co-administered Ozempic®

The risk of hypoglycemia may be lowered by a reduction in the dose of sulfonylurea (or other concomitantly administered insulin secretagogues) or insulin when starting treatment with Ozempic®

When Ozempic® 1 mg was added to an SGLT2i, severe or BG-confirmed hypoglycemia occurred in 2.7% of patients and documented symptomatic hypoglycemia occurred in 5.3% of patients, compared to none in the placebo-treated group

Diabetic retinopathy complications2,24

In a 2-year CVOT that investigated 3,297 patients with T2DM, an imbalance in diabetic retinopathy complications was observed in patients with a history of diabetic retinopathy (3% with Ozempic® vs. 1.8% with placebo)

In clinical trials up to 1 year involving 4,807 patients with T2DM, adverse events related to diabetic retinopathy were reported in similar proportions of patients treated with Ozempic® (1.7%) and comparators (2.0%)

Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy

In alignment with Diabetes Canada Guidelines, patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy2,25

BG, blood glucose; CVOT, cardiovascular outcome trial; SGLT2i, sodium-glucose cotransporter 2 inhibitor; T2DM, type 2 diabetes mellitus.

Contact us

Novo Nordisk would like every healthcare practitioner to be able to obtain information as easily and quickly as possible.
If you need information about Ozempic®, please contact:

Novo Nordisk Canada Inc.
101-2476 Argentia Road
Mississauga, Ontario
L5N 6M1

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Monday to Friday from
8:30 a.m. to 5:00 p.m. EST

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